[1] Cao Limin, Guan Shanshan, Zhang Peng,.Analgesic Effect of Pueraria Tongluo Granules [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2018, (01): 79-82,87. [doi: 10.13424/j.cnki.jsctcm.2018.01.026]
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Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R]
Volumes & Issues:
2018 01
pagination:
79-82,87
Column:
Publication date:
2018-01-10
- Article number:
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2096-1340(2018)01-0079-05
- Author(s):
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Cao Limin; Guan Shanshan; Zhang Peng
-
Yulin Hospital of Chinese Medicine,Shaanxi 719000,China
-
- Keywords:
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pueraria Tongluo granules; analgesic effect; 5 - hydroxytryptamine
- ZTFLH:
-
R285. 5
- DOI:
-
10.13424/j.cnki.jsctcm.2018.01.026
- Code:
-
A
- Abstract:
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To observe the analgesic effect and the mechanism of pueraria Tongluo granules. Method: 48
eligible mice were randomly divided into: model group,puerarin Tongluo low,medium and high dose groups ( 3. 0,6. 0,
12. 0g · kg-
1) ,in terms of crude drug,hereinafter referred to as GG low group,GG Group,GG high group) . Themodel group was treated with 0. 5% CMC - Na suspension ( 0. 2mL /10g) ,and hot plate method was used to observe the
change of pain threshold of mice. 50 eligible mice were randomly divided into model group,GG low group,GG Group,
GG high group and aspirin group( 0. 2g / kg) . 0. 5% CMC - Na suspension ( 0. 2mL / 10g) was given to the model group.
The mice in each group were injected intraperitoneally with 0. 6% acetic acid ( HAC) at 0. 1mL / 10g one hour after the
administration. Mice writhing reaction times were recorded and the inhibition rate was calculated. 50 eligible mice were
randomly divided into model group,GG low group,GG group,GG high group and blank control group,except the blank
control group,the other four groups were subcutaneously injected reserpine 1. 0mg / kg for continuous 10 days,the effect
of pueraria granules on 5 - HT content in mouse brain was observed. Result: Pain threshold: the pain thresholds of the
four groups of mice before treatment and 0. 5h after administration were not statistically significant ( P≥0. 05) . Compared
with the model group,the pain threshold of the GG high group was significantly increased at 1h,1. 5h and 2h ( P < 0. 01,
P < 0. 01,P < 0. 05,respectively) . Compared with the model group,the pain threshold of the GG group was significant-
ly increased at 1. 5h and 2h after administration ( P < 0. 05) ,the difference was statistically significant ( P < 0. 05) .
Compared with the model group at each time point,the difference of pain threshold of the GG low group was not statisti-
cally significant ( P≥0. 05) . Writhing times: Compared with the model group,the GG low,medium and high dose group
and aspirin group could significantly reduce the writhing times of mice induced by glacial acetic acid,and the difference
was statistically significant ( P < 0. 05) . 5 - HT content in brain: The neurotransmitter 5 - HT in the mice of the model
group was significantly lower than that in the normal mice ( P < 0. 05) ,GG high group showed a significant increase in 5
- DT and the difference had statistical significance( P < 0. 05) compared with the model group,5 - DT contents in GG
and GG high groups were also increased to some extent while the difference had no statistical significance ( P≥0. 05) .