[1] Wei Xiaoli
Jiang ui
Li Junhong Li Jing Lei Dongyu Jiang Ping,.The Effect of DanHong Injection on the Serum Metabolites
of SHR Based on NMR Technology [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2017, (04): 95-100. [doi: 10.13424/j.cnki.jsctcm.2017.04.032]
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Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R]
Volumes & Issues:
2017 04
pagination:
95-100
Column:
Publication date:
2017-07-05
- Article number:
-
2096-1340(2017)04-0095-06
- Author(s):
-
Wei Xiaoli
1 Jiang Rui
2 Li Junhong3 Li Jing3 Lei Dongyu3 Jiang Ping3
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1. Basic Medical Immunology Department,Xinjiang Medical University,Urumqi 830011,China;
2. The 6th Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;
3. Physiology Department,Basic Medical College of Xinjiang Medical University,Urumqi
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- Keywords:
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NMR technique; DanHong Injection; SHR; serum metabolites
- ZTFLH:
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R541.3
- DOI:
-
10.13424/j.cnki.jsctcm.2017.04.032
- Code:
-
A
- Abstract:
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Objective: To discuss the effect of DanHong Injection on the serum metabolites of spontaneously hypertensive
rats ( SHR) . Method: The SPF SHR of 8 - week - old experimental rats were randomly divided into two
groups: SHR group and DH group ( DanHong Injection intervention group of SHR rats) ,besides Wister - Kyoto rats of
the same age were selected as the control group of normal blood pressure ( WEY group) ,with 6 rats in each group. DH
group received DanHong Injection and SHR group the same amount of aseptic saline solution,both of which were injected
in the rat's abdominal cavity according to their weights ( 10mL/kg) and continuously administered for 28 days. Physiological
indexes of blood pressure and heart rate were checked and the levels of metabolites in the serum of rats were
measured by NMR. Results: The results showed that both the heart rate and blood pressure in SHR and DH group compared
with WKY group elevated in different degrees,having statistical meaning. In the comparison between DH and
SHR groups,the systolic and diastolic pressures all declined but the difference had no statistical meaning. Compared
with the WKY rat,the level of 15 metabolites in the SHR rats’serum changed,among which 8 decreased and 7 rose.
Conclusion: DanHong Injection is not effective in lowering the blood pressure of the SHR rats,but it can reverse thelevels of various metabolites in the rat serum and improve the internal environment to protect the body.